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目前，已報(bào)導(dǎo)的多肽縮合劑很多，但影響較大，應(yīng)用較為廣泛的縮合劑從分子結(jié)構(gòu)角度主要分為碳二亞胺類(lèi)型、磷正離子類(lèi)型和脲正離子類(lèi)型，其中以磷正離子和脲 正離子型縮合劑性能最佳。中華試劑網(wǎng)網(wǎng)提供幾十種高純縮合劑產(chǎn)品，諸如DIC、AOP、HOBt、HOAt等，可在溫和條件下參與反應(yīng)，反應(yīng)速度快、產(chǎn)物消旋小、收 率高，滿足“原子經(jīng)濟(jì)性”的需求，國(guó)內(nèi)現(xiàn)貨充足，批次質(zhì)量穩(wěn)定，已被眾多生產(chǎn)企業(yè)、科研機(jī)構(gòu)所使用
References
D. Gomez, R. Paterski, T.lt Lemarteleur, S.Y. Kazuo, J.L. Mergny, J.F. Riou, J. Biochemistry. 2004, 279, 41487–41494.
■ 碳二亞胺類(lèi)型縮合劑
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產(chǎn)品名稱(chēng)
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CAS
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包裝
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結(jié)構(gòu)式
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二環(huán)己基碳二亞胺
N,N'-Dicyclohexylcarbodiimide, DCC, 99%
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|
100 g
250 g
1 kg
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|
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N,N'-二異丙基碳二亞胺
N,N'-Diisopropylcarbodiimide, DIC, 99%
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|
5 g
25 g
100 g
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|
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N-(3-二甲氨基丙基)-N'-乙基碳二亞胺鹽酸鹽N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride, EDC.HCl, 99%
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10 g
50 g
100 g
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|
|
4,5-二氰基咪唑
4,5-Dicyanoimidazole, DCI, 99%
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|
1 g
5 g
25 g
|
|
|
N,N'-羰基二咪唑
N,N'-Carbonyldiimidazole , CDI, 98%
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|
25 g
100 g
500 g
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|
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N-羥基丁二酰亞胺
N-Hydroxysuccinimide, NHS (HOSu), 98%
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|
25 g
100 g
250 g
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|
|
N-羥基硫代琥珀酰亞胺鈉鹽
N-Hydroxysulfosuccinimide sodium salt, Sulfo-NHS, 98%
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|
1 g
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|
■ 磷正離子類(lèi)型縮合劑
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產(chǎn)品名稱(chēng)
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CAS
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包裝
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結(jié)構(gòu)式
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苯并三唑-1-三(三甲氨基)-六氟磷酸酯，卡特縮合劑
Benzotriazol-1-yloxytris(dimethylamino)-phosphonium hexafluorophosphate, BOP, 98%
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|
5 g
25 g
100 g
|
|
|
六氟磷酸苯并三唑-1-基-氧基三吡咯烷基膦
Benzotriazole-1-yl-oxy-trispyrrolidinophosphonium hexafluorophosphate, 99%, PyBOP
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1 g
5 g
25 g
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|
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三吡咯烷基溴化鏻六氟磷酸鹽
Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate, PyBrOP, 97%
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|
1 g
5 g
25 g
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|
■ 脲正離子類(lèi)型縮合劑
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產(chǎn)品名稱(chēng)
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CAS
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規(guī)格
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結(jié)構(gòu)式
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1-羥基-7-偶氮苯并三氮唑
1-Hydroxy-7-azabenzotriazole, HOAT, 98%
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|
1 g
5 g
25 g
|
|
|
1-羥基苯并三氮唑
1-Hydroxybenzotriazole[Anhydrous], HOBt anhydrous, 98%
|
|
5 g
25 g
100 g
|
|
|
6-氯-1-羥基苯并三氮唑
6-Chloro-1-hydroxybenzotriazol, Cl-HOBt, 98%
|
|
5 g
25 g
100 g
|
|
|
O-(7-氮苯并三氮唑)-N,N,N',N'-四甲基脲六氟磷酸酯
O-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate, HATU, 99%
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|
5 g
25 g
100 g
|
|
|
苯并三氮唑-N,N,N',N'-四甲基脲六氟磷酸酯
O-Benzotriazole-N,N,N',N'-tetramethyluronium hexafluorophosphate, HBTU, 99%
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|
1 g
5 g
25 g
|
|
|
O-苯并三氮唑-N,N,N',N'-四甲基脲四氟硼酸酯
O-(Benzotriazol-1-yl)-N,N,N',N'-tetra methyluronium tetrafluoroborate, TBTU, 97%
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|
5 g
25 g
100 g
|
|
|
6-氯苯并三氮唑-1,1,3,3-四甲基脲六氟磷酸酯O-(1H-6-Chlorobenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate, HCTU, 98%
|
|
5 g
25 g
100 g
|
|
|
O-(1,2-二氫-2-氧-吡啶基)-1,1,3,3-四甲基脲四氟硼酸鹽
O-(1,2-Dihydro-2-oxo-pyridyl)-1,1,3,3-tetramethyluronium tetrafluoroborate, TPTU, 99%
|
|
1 g
5 g
|
|
■ 其它類(lèi)型縮合劑
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產(chǎn)品名稱(chēng)
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CAS
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包裝
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結(jié)構(gòu)式
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|
N-乙氧碳?；?2-乙氧基-1,2-二氫喹啉
N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, EEDQ, 98%
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|
5 g
25 g
100 g
|
|
|
二(2-氧代-3-唑烷基)次磷酰氯
Bis(2-oxo-3-oxazolidinyl)phosphinic chloride, BOP-Cl, 97%
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1 g
5 g
25 g
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|
■ 配套試劑
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產(chǎn)品名稱(chēng)
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CAS
|
包裝
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甲醇
Methanol [HPLC/PREP], 99.8%
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20 L
200 L
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乙腈
Acetonitrile [HPLC/PREP], 99.8%
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|
20 L
200 L
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|
三氟乙酸
Trifluoroacetic acid, 99.9% [≤10 APHA]
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|
250 mL
4 L
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N,N-二異丙基乙胺
N,N-Diisopropyl ethylamine, 99.5%
|
|
500 mL
2.5 L
20 L
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